Study record managers: refer to the Data Element Definitions if submitting registration or results information. Overall response. Talk with your doctor and family members or friends about deciding to join a study.
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Ex-vivo cultured adult human mesenchymal stem cells
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Human mesenchymal stem cells HMSCs which are isolated from bone marrow stroma, peripheral blood, dermis, muscle and adipose tissue have the advantage of potential autologous transplantation ability. They can be differentiated into chondrogenic, osteogenic, adipogenic and myogenic lineages. Problems of stem cells from bone marrow are low cell numbers, low isolated volumes, pain, and to some extent ethical concerns. The isolation of mesenchymal stem cells from human adipose tissue was recently identified as an alternative source, since these cells are easy to obtain in big cell numbers. Adipose tissue is derived from embryonic mesoderm and contains a heterogeneous stromal cell population. To achieve lineage-specific differentiation of these cells they have to be cultured in media supplemented with appropriate factors. Inductions of the cells into multiple mesenchymal lineages resulted in the expression of several lineage-specific genes, proteins and specific metabolic activity. In conclusion, the potential benefit of the multi-germline capacity of HMSCs seems to be a promising approach for allogenic cell therapy and human tissue engineering.
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Stem Cell Engineering pp Cite as. Mesenchymal stem cells MSCs can be found in various tissues of the adult organism. These cells display a multilineage potential and can be in vitro differentiated toward the osteogenic, adipogenic, chondrogenic, and myogenic lineage, which makes them promising candidates for future tissue replacement strategies. My cooperation partners Dr. Hermann Lang, University of Rostock, provided beautiful pictures for this work. Without their highly appreciated input, this chapter would have been way less vivid. I thank Juliane Czeczor for drawing the scheme. Skip to main content. Advertisement Hide.